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Blocking a common immune system response cleared up plaques associated with Alzheimer’s Disease and enabled treated mice to recover some lost memory, Yale University researchers report Friday in the journal Nature Medicine. Researchers hope the new approach may one day overcome one of the biggest obstacles to development of new dementia medications - the difficulty in finding drugs that can safely cross the blood-brain barrier.

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Interrupting a signaling pathway in certain immune system cells in laboratory mice had the opposite effect researchers expected but opened the possibility of a new approach to treating Alzheimer’s disease, according to an article in the journal Nature Medicine.The intervention targets the sticky plaque buildup that occurs in the brains of patients with Alzheimer’s disease, using immune system cells (macrophages) from outside the brain.

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Health Minister Ivan Lewis helped launch Alzheimer’s Society’s new public information campaign to raise awareness of dementia, its symptoms and the importance of getting an early diagnosis. Called Worried About Your Memory?, the campaign will prompt and help people to consider if their forgetfulness, or that of a friend or relative, is due to just poor memory or the beginning of a medical problem and encourage them to seek medical advice.

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Different types of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, and aspirin, appear to be equally effective in lowering the risk of Alzheimer’s disease, according to the largest study of its kind published in the May 28, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Alzheimer’s Society comment on new research showing that short term use of antipsychotic drugs more than triple the risk of a serious event causing hospitalisation or death in people with dementia living in the community.This comprehensive study highlights the life-threatening effects antipsychotics have on people with dementia and reveals that people in the community are at greater risk than those in nursing homes.

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Action on Elder Abuse, (AEA) the leading specialist charity focussing upon the abuse of older people, has welcomed today’s announcement that the Government is to enshrine a patient’s right to dignity within the NHS constitution. Gary FitzGerald, Chief Executive of AEA, said “We have seen too many instances where older people have experienced care within hospitals which has fallen far short of our collective expectations.

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Project StoryKeeper, a non-profit organization dedicated to preserving family heritage and announced that new findings by the Alzheimer’s Association are increasing the need to document the life stories of patients. Caregivers of Alzheimer’s patients can get access to Project StoryKeeper’s interviewing technology by visiting http://www.storykeeper.org.

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A number of chronic diseases are in fact caused by one or more infectious agents. For example, stomach ulcers are caused by Helicobacter pylori, chronic lung disease in newborns and chronic asthma in adults are both caused by Mycoplasmas and Chlamydia pneumonia, while some other pathogens have been associated with atherosclerosis. The realization that pathogens can produce slowly progressive chronic diseases has opened new lines of research into Alzheimer’s disease.

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People with dementia are entitled to the same dignity and quality of care as any other patient, but the symptoms of this devastating condition can make this a real challenge. People may find their dignity is compromised by problems with communication. In these situations the support of dementia trained care staff can make all the difference to their quality of life.

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New GMC guidance launched urges doctors to rethink their approach to discussing medical issues with their patients. Doctors should actively engage patients in discussions, allowing them to make decisions based on their individual needs and circumstances. As part of this approach, consent should not be seen as a tick box exercise, but as part of a wider decision making process, in which both parties have an important role to play.

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