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A vaccine created by University of Rochester Medical Center scientists prevents the development of Alzheimer’s disease-like pathology in mice without causing inflammation or significant side effects.Vaccinated mice generated an immune response to the protein known as amyloid-beta peptide, which accumulates in what are called “amyloid plaques” in brains of people with Alzheimer’s.

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Better targeted education is needed to prevent misconceptions held by the general public about Alzheimer’s disease, according to Queensland University of Technology researcher Dr Karen Sullivan. Registered psychologist and senior lecturer for the School of Psychology and Counselling in the Faculty of Health, Dr Sullivan has been studying people’s misconceptions about the condition for the past five years, and said there were a number of things which people misunderstood about it.

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A new study has identified the cause of late-onset Alzheimer’s disease in several large families in which many siblings suffer from the disease. The gene, known as TRPC4AP on chromosome 20, is involved with calcium regulation. It is known that when calcium levels are not carefully controlled, cells can die, leading to the onset of disease. Alzheimer’s disease is a complex progressive neurodegenerative disorder in which patients suffer from profound cognitive decline.

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Researchers from the University of Pennsylvania School of Medicine have shown, in unprecedented detail, how a small molecule is able to selectively take apart abnormally folded protein fibers connected to Alzheimer’s disease and prion diseases. The findings appeared online in the Proceedings of the National Academy of Sciences. Finding a way to dismantle misfolded proteins has implications for new treatments for a host of neurodegenerative diseases.

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U.S. Senate Special Committee on Aging Chairman Herb Kohl (D-WI) held a hearing on Alzheimer’s, a disease that currently affects over five million Americans and their families. Witnesses provided an update on the latest research and treatments, issues surrounding early-onset diagnoses, the importance of training and support for patient caregivers, and the need for a comprehensive strategy as more and more Americans are diagnosed with the disease.

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Researchers at the Yerkes National Primate Research Center, Emory University, have discovered the first conclusive evidence of Alzheimer’s-like neurofibrillary brain tangles in an aged nonhuman primate.

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Applied NeuroSolutions, Inc. (OTC BB:APNS)( http://www.AppliedNeuroSolutions.com), a company focused on the development of products for the early diagnosis and treatment of Alzheimer’s disease (”AD”), today announced an initiative to provide its P-Tau 231 cerebrospinal fluid (CSF) test to companies undertaking AD clinical trials.

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The genetic profile of two large Georgia families with high rates of late-onset Alzheimer’s disease points to a gene that may cause the disease, researchers say.Genetic variations called single nucleotide polymorphisms, or SNPs, are common in DNA, but this pattern of SNPs shows up in nine out of 10 affected family members, says Dr. Shirley E.

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Help the Aged have backed an MPs bid to regulate the prescription of anti-psychotic drugs for people with dementia in care homes.

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There is an urgent need to improve end-of-life care for older people in the final stages of dementia, according to an international review published in the May issue of Journal of Clinical Nursing. “We must act now to stop people with dementia from suffering from protracted, potentially uncomfortable and undignified deaths” says Jan Draper, Professor of Nursing for The Open University, UK.

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