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For the first time, researchers have described hour-by-hour changes in the amount of amyloid beta, a protein that is believed to play a key role in Alzheimer’s disease, in the human brain. A collaborative team of scientists at Washington University School of Medicine in St. Louis and the University of Milan report their results in Science.

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A new study shows that older people’s mental skills start declining years before death, even if they don’t have dementia. The study is published in the August 27, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. “These changes are different and separate from the changes in thinking skills that occur as people get older,” said study author Valgeir Thorvaldsson, MSc, of Goteberg University in Sweden.

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A new study shows that older people’s mental skills start declining years before death, even if they don’t have dementia. The study is published in the August 27, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. “These changes are different and separate from the changes in thinking skills that occur as people get older,” said study author Valgeir Thorvaldsson, MSc, of Goteberg University in Sweden.

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Alzheimer’s Society comment on the announcement by Carol Thatcher that Baroness Thatcher has dementia. The sad news that Baroness Thatcher has dementia has highlighted a condition that is desperately under recognised and underfunded in the UK. One in three people over 65 will die with a form of dementia. Dementia is not a natural part of ageing; it is caused by diseases of the brain and robs people of their lives.

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The Alzheimer’s Drug Discovery Foundation (ADDF), a public charity founded by the Estee Lauder family in 2004, is pleased to announce an exciting partnership with extreme athlete, former Marine, and elite personal trainer Mike Monroe. Mike will be raising money for the ADDF in the 25th anniversary Furnace Creek 508 (The 508) bicycle race on October 4-6, 2008, http://www.the508.com.

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Alzheimer Scotland welcomes the attention drawn to ‘inconsistencies’ in palliative care for different conditions in the recent Review of palliative care services in Scotland report from Audit Scotland. This report has prompted a pledge from the Scottish Government for a national plan to improve palliative care provision.

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A hallmark of this year’s ICAD meeting was the wealth of new clinical trials information in Alzheimer’s Disease (AD). Years of basic and preclinical research have paved the road for development of new medications and biologics. Results from many new clinical trials were provided, ranging from promising Phase I and II trials to some disappointing Phase II and III results. Hundreds of new agents for the treatment of dementias are now in or approaching clinical trials.

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New research led by Chu Chen, PhD, Associate Professor of Neuroscience at LSU Health Sciences Center New Orleans, provides evidence that one of the only naturally occurring fatty acids in the brain that has the ability to interact with the receptors originally identified as the targets of THC (the psychoactive component of marijuana) can help to protect brain cells from neurodegenerative diseases like Alzheimer’s and Parkinson’s.

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New research suggests that a select group of compounds that interact with a protein in the brain might be used in the early diagnosis and treatment of Alzheimer’s disease and other dementia disorders. Scientists have discovered that these compounds interact in three specific ways with the tau protein, which is the subject of a growing body of research into the causes and progression of dementia.

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MIT engineers report a new approach to identifying protein structures key to Alzheimer’s disease, an important step toward the development of new drugs that could prevent such structures from forming. In the Aug. 22 issue of PLoS (Public Library of Science) Computational Biology, the researchers describe one such structure uncovered using a new computer-based technique. Collin M. Stultz, the leader of the work and the W.M.

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