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There is growing concern about conflicts of interest in clinical research, including research sponsors paying finders’ fees to researchers and clinicians to recruit participants. Institutional review boards can help prevent such conflicts, which may compromise the integrity of the research and potentially harm research subjects. But an article in IRB: Ethics & Human Research reviews IRB policies and finds room for improvement.

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One million people will develop dementia in the next 10 years so there is a desperate need to find ways to prevent dementia. ‘The idea that ‘brain training’ may prevent cognitive decline is extremely attractive, but worryingly there is only very limited evidence. Alzheimer’s Society wants to see robust research into whether brain training can reduce your risk of developing dementia.

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Researchers at NYU Langone Medical Center have discovered a novel way to stimulate the innate immune system of mice with Alzheimer’s disease (AD) - leading to reduced amyloid deposits and the prevention of Alzheimer’s disease related pathology - without causing toxic side effects. The study entitled “Induction of Toll-like Receptor 9 Signaling as a Method for Ameliorating Alzheimer’s Disease Related Pathology” was published in The Journal of Neuroscience.

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Using special MRI methods, researchers have identified a pattern of regional brain atrophy in patients with mild cognitive impairment (MCI) that indicates a greater likelihood of progression to Alzheimer’s disease. The findings are published in the online edition of Radiology. “Previously, this pattern has been observed only after a diagnosis of probable Alzheimer’s disease,” said the study’s lead author, Linda K. McEvoy, Ph.D.

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Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) (the “Company” or “Ligand”) today announced that it has earned a $1 million milestone payment from Schering-Plough Corporation (NYSE: SGP) related to the progress of Schering-Plough’s inhibitor of β-site of APP cleaving enzyme (BACE) for the treatment of Alzheimer’s disease, which resulted from a research collaboration with Pharmacopeia (acquired by Ligand).

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Researchers in the US found that people whose diet is closer to a Mediterranean diet are at lower risk of developing MCI or Mild Cognitive Impairment (a stage between normal aging and dementia) and also have a reduced risk of MCI turning into Alzheimer’s disease.

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A new study from Lifespan evaluated the research to date on the impact of cognitive training on the healthy elderly population. Their review of all relevant randomized, controlled trials shows no evidence that structured cognitive interventions or “brain exercise” programs delay or slow progression of cognitive changes in healthy elderly. Such programs are now an $80 million per year industry. The study appeared in Alzheimer’s & Dementia.

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Doctors may be able to use certain cognitive tests to help determine whether a person with Alzheimer’s disease can safely get behind the wheel. The research is published in the February 10, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.

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The Lewy Body Society heartily welcomes the publication of the Government’s National Dementia Strategy , published last week, for which £150 million has been earmarked for dementia care over the next two years. Measures to be undertaken include the appointment of a senior clinician in every hospital and care home in England, who will be responsible for seeing that the needs of dementia sufferers are met.

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The Alzheimer’s Drug Discovery Foundation (ADDF) and the Association for Frontotemporal Dementia (AFTD) announced today the recipients of their second annual research award, Frontotemporal Dementia Drug Discovery Program. The goal of the program is to accelerate the development of novel therapies for frontotemporal dementia (FTD). The ADDF/AFTD program awarded $300,000 to three academic scientists on the cutting edge of research for FTD.

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