Scientists have unraveled in unprecedented detail the cascade of events that go wrong in brain cells affected by HIV, a virus whose assault on the nervous system continues unabated despite antiviral medications that can keep the virus at bay for years in the rest of the body. The new research reveals key steps taken in the brain by Tat, a protein that is central to HIV’s attack on cells called neurons.
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Researchers at Southern Methodist University (SMU) and The University of Texas at Dallas (UTD) have identified a group of chemical compounds that slow the degeneration of neurons, a condition behind old-age diseases like Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS). Their findings are featured in the November 2008 edition of Experimental Biology and Medicine. SMU Chemistry Professor Edward R.
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University of Central Florida students are helping people with Alzheimer’s disease and related disorders through an innovative program that blends traditional therapy along with games such as the Wii and yoga. Media are invited to attend a session from 10 a.m. to noon on Friday, Nov. 14, or Friday, Nov. 21, at First United Methodist Church of Winter Park, 125 N. Interlachen Ave.
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Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at LSU Health Sciences Center New Orleans, is the lead author of a paper identifying, for the first time, a specific function of a fragment of ribonucleic acid (RNA), once thought to be no more than a byproduct, in regulating inflammation and the development of Alzheimer’s disease.
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The only known genetic risk factor for Alzheimer’s disease slows down the brain’s ability to export a toxic protein known as amyloid-beta that is central to the damage the disease causes, scientists have found. The research, published Nov. 13 by the Journal of Clinical Investigation, provides new clues into the workings of a protein known as apolipoprotein E4, or ApoE4.
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Saint Louis University researchers have identified a novel way of getting a potential treatment for Alzheimer’s disease and stroke into the brain where it can do its work. “We found a unique approach for delivering drugs to the brain,” says William A. Banks, M.D., professor of geriatrics and pharmacological and physiological science at Saint Louis University. “We’re turning off the guardian that’s keeping the drugs out of the brain.
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For the first time researchers have shown that a commonly used anesthetic can produce changes associated with Alzheimer’s disease in the brains of living mammals, confirming previous laboratory studies. In their Annals of Neurology report, which has received early online release, a team of Massachusetts General Hospital (MGH) investigators shows how administration of the gas isoflurane can lead to generation of the toxic amyloid-beta (A-beta) protein in the brains of mice.
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Researchers from the Peninsula Medical School, Plymouth Hospitals NHS Trust and the University of Plymouth, have received a grant funding of £2million over the next five years from the National Institute for Health Research (NIHR) to investigate new ways of developing clinical trials for the treatment of Alzheimer’s disease and Parkinson’s disease.
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Linguistic techniques could be useful for assessing communications problems in people with dementia. Examining a person’s diary could give valuable insight into how a person’s communication skills have changed over time and help with diagnosis. Harold Wilson’s speeches may be part of political history, but they could form an important part of our current battle against dementia.
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Alzheimer’s Society has welcomed draft regulations for direct payments today as the Department of Health consultation closes. The draft regulations extend direct payments to people who lack capacity and remove the blanket exclusion that currently applies to people who are subject to various provisions of mental health legislation. Extending direct payments will help to give more people with dementia choice and control over their lives.
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